Investigating nucleation and growth phenomena in microfluidic supercritical antisolvent process by coupling in situ fluorescence spectroscopy and direct numerical simulation
نویسندگان
چکیده
High-pressure microfluidic systems exhibit favorable capacity to enhance mixing quality compared conventional macroscale liquid systems. These conditions are very interesting for the preparation of fluorescent organic nanoparticles by supercritical antisolvent process. In this work, fundamental mechanisms process (µSAS) including thermodynamics, hydrodynamics, nucleation/growth phenomena, investigated using a coupled experimental/simulation approach. Specifically, we determined experimentally particle precipitation field in CO2 / solvent medium dye molecule which presents an enhancement fluorescence intensity its aggregated state (AIE effect). The results direct numerical simulation considering all physical phenomena with experimental data validation and deep understanding mechanisms. It is shown that despite ultra-short time, supersaturation showed some fluctuation leading variation nucleation times.
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ژورنال
عنوان ژورنال: Chemical Engineering Science
سال: 2022
ISSN: ['1873-4405', '0009-2509']
DOI: https://doi.org/10.1016/j.ces.2021.117240